openfold3

A drop-in, hardware-agnostic library for Fused Triangle Multiplicative Updates across AlphaFold3-family models, powered by CUTLASS CuTe kernels.

OpenFold3 Input Builder.

PDE10A protein-ligand co-folding analysis with OpenFold3 - built for the Apheris x OpenFold track at BioIncubate's Catalyst hackathon at ETH Zurich.

Open-source autonomous in silico drug-discovery pipeline for Korean traditional medicine: Boltz-2 + OpenFold3 + AQAffinity + REINVENT4 + OpenMM ABFE + cost-aware multi-fidelity BO scheduler. 19 bioRxiv preprints. Recover Korean Medicine Clinic (Seoul, 2026-08-15 opening) translational anchor.

Target-specific fine-tuning for OpenFold3 — data prep, training, and evaluation in one reproducible pipeline.

RNA 3D structure prediction with template + SS-MSA guidance for OpenFold3 and Boltz-2, benchmarked against baselines.

Fine-tuning OpenFold3 (4.0.0) for PDE10A protein–ligand pose prediction via distribution-aware PDB-scale data augmentation: +0.20 PL LDDT, −2.3 Å ligand RMSD on held-out.