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populationgenetics

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clay-good / alleleforge

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A variant-first, multi-modality CRISPR design framework that unifies SpCas9 nuclease, base-editor, and prime-editor chemistries under a single typed interface to deliver ranked candidate edits complete with calibrated uncertainty intervals, predicted outcome distributions, and ancestry-stratified, population-aware off-target safety reporting.

python rust machine-learning bioinformatics deep-learning genomics computational-biology crispr variant-calling clinvar uncertainty-estimation genome-editing benchmark-datasets pyo3 base-editing populationgenetics prime-editing haplotype-mapping off-target-analysis guide-rna-design
  • Updated Aug 12, 2026
  • Python

mhashemihsmw / MOI-bias-correction

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Repository of R functions and files to derive estimates and generate simulated data according to the methods and models described in "Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies". To import/merge molecular data of any type (STR, SNPs, amino acids) and format and apply further analysis use R/MLMO

statistical-learning biostatistics statistical-inference datavisualization dataanalysis populationgenetics
  • Updated Nov 27, 2023
  • R

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