Build somatic hypermutation (SHM) lineage trees from antibody repertoire sequencing data. Reconstruct clonal relationships between antibody sequences and visualize how B-cell receptor (BCR) clones diversify during somatic hypermutation and affinity maturation.
A zero-dependency C++ wrapper for NCBI IgBLAST. Embeds IMGT databases and binaries into a single executable for standalone V(D)J assignment and enriched AIRR-formatted outputs.
Reproducible analysis of bulk TCR and BCR repertoires (AIRR format): diversity at common depth, differential abundance, clone tracking, specificity annotation
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