diff --git a/cassandra/connection.py b/cassandra/connection.py
index d0a75818b2..fc9b22b381 100644
--- a/cassandra/connection.py
+++ b/cassandra/connection.py
@@ -496,6 +496,15 @@ def __repr__(self):
 
 
 class _Frame(object):
+    __slots__ = (
+        'version',
+        'flags',
+        'stream',
+        'opcode',
+        'body_offset',
+        'end_pos',
+    )
+
     def __init__(self, version, flags, stream, opcode, body_offset, end_pos):
         self.version = version
         self.flags = flags