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@@ -110,6 +110,7 @@ tutorials/notebooks/notebooks.md
 tutorials/notebooks/datasets/README.md
 glossary.md
 design_doc.md
+interoperability.md
 contributing.md
 changelog.md
 references.md
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+# Interoperability
+
+The on-disk representation of SpatialData can be read from other languages. Here we list interfaces for working with SpatialData from your language of choice:
+
+## R
+
+- [spatialdataR](https://helenalc.github.io/spatialdataR/) provides an R implementation of the `SpatialData` object, with out-of-memory images and labels, `duckdb`-backed points and shapes, and tables represented as `SingleCellExperiment` objects.
+
+## JavaScript and TypeScript
+
+- [SpatialData.js](https://github.com/Taylor-CCB-Group/SpatialData.js) provides a TypeScript and JavaScript library for interfacing with SpatialData stores.
+- [Vitessce](https://vitessce.io/docs/data-file-types/#spatialdatazarr) reads `spatialdata.zarr` stores directly and uses them for interactive visualization.
+
+## File format
+
+The SpatialData on-disk format builds on [OME-NGFF](https://ngff.openmicroscopy.org/latest/). See the [design document](design_doc.md) for details of the current on-disk layout.