diff --git a/mypyc/codegen/emitclass.py b/mypyc/codegen/emitclass.py
index 69c0b3e7c8c6..6d3ba761426e 100644
--- a/mypyc/codegen/emitclass.py
+++ b/mypyc/codegen/emitclass.py
@@ -53,6 +53,13 @@
 
 
 def native_slot(cl: ClassIR, fn: FuncIR, emitter: Emitter) -> str:
+    """Use a native method directly as a slot that takes self and returns an object.
+
+    If the method returns an unboxed value, such as an int from __next__, a wrapper
+    that boxes the value fills the slot instead.
+    """
+    if fn.ret_type.is_unboxed:
+        return generate_dunder_wrapper(cl, fn, emitter)
     return f"{NATIVE_PREFIX}{fn.cname(emitter.names)}"
 
 
diff --git a/mypyc/test-data/run-dunders.test b/mypyc/test-data/run-dunders.test
index 370de875b556..1159a0af6d1b 100644
--- a/mypyc/test-data/run-dunders.test
+++ b/mypyc/test-data/run-dunders.test
@@ -409,6 +409,182 @@ class InterpOverride(C):
     def __index__(self) -> int:
         return 2
 
+[case testDundersNext]
+from typing import Any
+
+from mypy_extensions import i64, mypyc_attr
+from testutil import assertRaises
+
+@mypyc_attr(allow_interpreted_subclasses=True)
+class Counter:
+    def __init__(self, n: int) -> None:
+        self.i = 0
+        self.n = n
+
+    def __iter__(self) -> "Counter":
+        return self
+
+    def __next__(self) -> int:
+        if self.i == self.n:
+            raise StopIteration
+        self.i += 1
+        return self.i
+
+class Inherit(Counter):
+    pass
+
+class Override(Counter):
+    def __next__(self) -> int:
+        return super().__next__() * 10
+
+class Container:
+    def __iter__(self) -> Counter:
+        return Counter(3)
+
+class BoolIter:
+    def __init__(self, items: list[bool]) -> None:
+        self.items = items
+
+    def __iter__(self) -> "BoolIter":
+        return self
+
+    def __next__(self) -> bool:
+        if not self.items:
+            raise StopIteration
+        return self.items.pop(0)
+
+class FloatIter:
+    def __init__(self, items: list[float], fail: bool = False) -> None:
+        self.items = items
+        self.fail = fail
+
+    def __iter__(self) -> "FloatIter":
+        return self
+
+    def __next__(self) -> float:
+        if not self.items:
+            if self.fail:
+                raise ValueError("bad float")
+            raise StopIteration
+        return self.items.pop(0)
+
+class I64Iter:
+    def __init__(self, items: list[i64]) -> None:
+        self.items = items
+
+    def __iter__(self) -> "I64Iter":
+        return self
+
+    def __next__(self) -> i64:
+        if not self.items:
+            raise StopIteration
+        return self.items.pop(0)
+
+class TupleIter:
+    def __init__(self) -> None:
+        self.items = [(1, "a"), (2, "b")]
+
+    def __iter__(self) -> "TupleIter":
+        return self
+
+    def __next__(self) -> tuple[int, str]:
+        if not self.items:
+            raise StopIteration
+        return self.items.pop(0)
+
+class StrIter:
+    def __init__(self) -> None:
+        self.items = ["a", "b"]
+
+    def __iter__(self) -> "StrIter":
+        return self
+
+    def __next__(self) -> str:
+        if not self.items:
+            raise StopIteration
+        return self.items.pop(0)
+
+class Raises:
+    def __iter__(self) -> "Raises":
+        return self
+
+    def __next__(self) -> int:
+        raise ValueError("bad next")
+
+def test_int() -> None:
+    assert list(Counter(3)) == [1, 2, 3]
+    c = Counter(2)
+    assert next(c) == 1
+    assert next(c) == 2
+    with assertRaises(StopIteration):
+        next(c)
+    assert next(c, -1) == -1
+    result = []
+    for x in Counter(3):
+        result.append(x)
+    assert result == [1, 2, 3]
+    assert [x * 2 for x in Counter(3)] == [2, 4, 6]
+    assert list(Container()) == [1, 2, 3]
+
+def test_int_generic() -> None:
+    a: Any = Counter(3)
+    assert next(a) == 1
+    assert a.__next__() == 2
+    assert list(a) == [3]
+    with assertRaises(StopIteration):
+        a.__next__()
+
+def test_subclasses() -> None:
+    assert list(Inherit(3)) == [1, 2, 3]
+    assert list(Override(3)) == [10, 20, 30]
+
+def test_other_unboxed_types() -> None:
+    assert list(BoolIter([False, True, False])) == [False, True, False]
+    assert list(BoolIter([True, False])) == [True, False]
+    # -113.0 and -113 are the error values of float and i64.
+    assert list(FloatIter([1.5, -113.0, 2.0])) == [1.5, -113.0, 2.0]
+    assert list(I64Iter([1, -113, 2])) == [1, -113, 2]
+    assert list(TupleIter()) == [(1, "a"), (2, "b")]
+
+def test_boxed_type() -> None:
+    assert list(StrIter()) == ["a", "b"]
+
+def test_errors() -> None:
+    with assertRaises(ValueError, "bad next"):
+        list(Raises())
+    with assertRaises(ValueError, "bad next"):
+        next(Raises())
+    with assertRaises(ValueError, "bad float"):
+        list(FloatIter([1.0], fail=True))
+
+def test_interpreted() -> None:
+    from interp import InterpInherit, InterpOverride, call_next, consume
+
+    assert consume(Counter(3)) == [1, 2, 3]
+    assert call_next(Counter(3)) == 1
+    assert consume(BoolIter([False, True])) == [False, True]
+    assert consume(TupleIter()) == [(1, "a"), (2, "b")]
+    assert consume(InterpInherit(2)) == [1, 2]
+    assert consume(InterpOverride(2)) == [101, 102]
+
+[file interp.py]
+from typing import Any
+
+from native import Counter
+
+class InterpInherit(Counter):
+    pass
+
+class InterpOverride(Counter):
+    def __next__(self) -> int:
+        return super().__next__() + 100
+
+def consume(it: Any) -> list[Any]:
+    return [x for x in it]
+
+def call_next(it: Any) -> Any:
+    return it.__next__()
+
 [case testDundersBinarySimple]
 from typing import Any