diff --git a/src/courseware/course/sequence/SequenceContent.jsx b/src/courseware/course/sequence/SequenceContent.jsx
index 6caa0fce27..d5b4007414 100644
--- a/src/courseware/course/sequence/SequenceContent.jsx
+++ b/src/courseware/course/sequence/SequenceContent.jsx
@@ -24,6 +24,19 @@ const SequenceContent = ({
   // Go back to the top of the page whenever the unit or sequence changes.
   useEffect(() => {
     global.scrollTo(0, 0);
+    // Move focus after every unit navigation so keyboard and screen-reader users
+    // are not left stranded on the next/previous button that triggered it.
+    // Targets div.app-container (the MFE root), which is always present regardless of
+    // plugin slot customization.
+    const mainContainer = global.document.querySelector('div.app-container');
+    if (mainContainer) {
+      if (!mainContainer.hasAttribute('tabindex')) {
+        mainContainer.setAttribute('tabindex', '-1');
+      }
+      mainContainer.focus();
+    } else {
+      global.document.body.focus();
+    }
   }, [sequenceId, unitId]);
 
   if (gated) {
diff --git a/src/courseware/course/sequence/SequenceContent.test.jsx b/src/courseware/course/sequence/SequenceContent.test.jsx
index e9c3a2d785..eec2edc401 100644
--- a/src/courseware/course/sequence/SequenceContent.test.jsx
+++ b/src/courseware/course/sequence/SequenceContent.test.jsx
@@ -1,4 +1,5 @@
 import React from 'react';
+import { act } from '@testing-library/react';
 import { initializeTestStore, render, screen } from '../../../setupTest';
 import SequenceContent from './SequenceContent';
 
@@ -42,4 +43,44 @@ describe('Sequence Content', () => {
     render(<SequenceContent {...mockData} unitId="" />, { wrapWithRouter: true });
     expect(screen.getByText('There is no content here.')).toBeInTheDocument();
   });
+
+  it('moves focus to div.app-container after unit navigation', async () => {
+    // JSDOM does not include the app shell markup, so we create the element manually
+    // to match the real DOM structure the focus logic targets.
+    const appContainer = global.document.createElement('div');
+    appContainer.className = 'app-container';
+    global.document.body.appendChild(appContainer);
+
+    const secondUnitId = store.getState().models.sequences[mockData.sequenceId].unitIds[1];
+    render(<SequenceContent {...mockData} />, { store, wrapWithRouter: true });
+
+    // Simulate navigating to the next unit by re-rendering with a new unitId.
+    // A second render call is used instead of rerender because rerender bypasses
+    // the store and provider wrappers from setupTest's custom render helper.
+    // We use act to flush the useEffect triggered by the unitId change.
+    await act(async () => {
+      render(<SequenceContent {...mockData} unitId={secondUnitId} />, { store, wrapWithRouter: true });
+    });
+
+    expect(appContainer).toHaveAttribute('tabindex', '-1');
+    expect(appContainer).toHaveFocus();
+
+    global.document.body.removeChild(appContainer);
+  });
+
+  it('falls back to focusing document.body when div.app-container is absent', async () => {
+    // Verify div.app-container is not in the DOM for this test — if a previous
+    // test left one behind, this assertion would give a false negative.
+    expect(global.document.querySelector('div.app-container')).toBeNull();
+
+    const secondUnitId = store.getState().models.sequences[mockData.sequenceId].unitIds[1];
+    render(<SequenceContent {...mockData} />, { store, wrapWithRouter: true });
+
+    // A second render call is used instead of rerender — see comment above.
+    await act(async () => {
+      render(<SequenceContent {...mockData} unitId={secondUnitId} />, { store, wrapWithRouter: true });
+    });
+
+    expect(global.document.body).toHaveFocus();
+  });
 });