Issues

• test(ci): dont make live network requests

  ga4gh/vrs-python#659 · Filter by author korikuzma opened on Sep 28, 2026

• Update to pysam>=0.24.0

  ga4gh/vrs-python#653 · Filter by author theferrit32 opened on Sep 1, 2026

• Update models to reflect new gkm-core and vrs minor releases

  enhancement
  Feature

  ga4gh/vrs-python#651 · Filter by author korikuzma opened on Sep 1, 2026
  1

  

• Add Relative Allele Normalization

  ga4gh/vrs-python#641 · Filter by author korikuzma opened on Jul 16, 2026
  

• Add Adjacency Normalization

  ga4gh/vrs-python#640 · Filter by author korikuzma opened on Jul 16, 2026

• Add support for switching RLE subunit between largest and smallest

  ga4gh/vrs-python#637 · Filter by author theferrit32 opened on Jun 5, 2026
  1

  

• Support to_hgvs for protein variants

  enhancementpriority:low
  ga4gh/vrs-python#633 · Filter by author theferrit32 opened on Apr 30, 2026
  1

• HgvsTools.is_intronic misses intronic r. (RNA) variants

  bugv3
  ga4gh/vrs-python#628 · Filter by author theferrit32 opened on Apr 17, 2026
  1

• Add Adjacency Translator

  enhancement
  ga4gh/vrs-python#627 · Filter by author korikuzma opened on Apr 17, 2026
  

• Replace DataProxy.get_metadata with get_length and get_aliases

  ga4gh/vrs-python#624 · Filter by author theferrit32 opened on Apr 14, 2026
  4

• Rename translate from/to

  ga4gh/vrs-python#623 · Filter by author korikuzma opened on Apr 13, 2026
  1

• Translator should support HGVS splice variants

  ga4gh/vrs-python#612 · Filter by author korikuzma opened on Feb 3, 2026
  

• Add translator support for uncertain range HGVS expressions

  ga4gh/vrs-python#609 · Filter by author theferrit32 opened on Jan 23, 2026
  

• Subclass of AbstractVcfAnnotator can decide to abort annotation

  ga4gh/vrs-python#605 · Filter by author ehclark opened on Jan 2, 2026

• Investigate integrating with DuckDB/Object storage vs. postgres requirement

  v3
  ga4gh/vrs-python#600 · Filter by author david4096 opened on Dec 17, 2025
  1

  

• Integrate seqrepo builds from github actions to vrs-in-a-box

  ga4gh/vrs-python#599 · Filter by author david4096 opened on Dec 17, 2025

• RLE_SEQ_LIMIT should be configurable

  ga4gh/vrs-python#598 · Filter by author korikuzma opened on Dec 15, 2025

• Add a function to recursively add IDs to a VRS object and every contained identifiable object

  enhancement
  ga4gh/vrs-python#596 · Filter by author jsstevenson opened on Dec 4, 2025
  2

• Create VcfReader class or standalone function which takes INFO key-value pairs and reconstructs VRS Alleles

  ga4gh/vrs-python#595 · Filter by author theferrit32 opened on Dec 3, 2025
  1

• hgvs to vrs conversion fails with repeat sequence notation

  ga4gh/vrs-python#582 · Filter by author spencerseale opened on Sep 18, 2025
  1

• Upgrade to hgvs 2.0.0a0

  buildv3
  ga4gh/vrs-python#579 · Filter by author korikuzma opened on Aug 15, 2025
  2

  

• Add additional input/output methods to the vrs-annotate CLI

  ga4gh/vrs-python#572 · Filter by author theferrit32 opened on Jul 24, 2025
  1

• Add VRS annotator example workflows

  ga4gh/vrs-python#571 · Filter by author theferrit32 opened on Jul 23, 2025
  2

• Set up docker builds and publishing to ga4gh dockerhub namespace

  ga4gh/vrs-python#570 · Filter by author theferrit32 opened on Jul 23, 2025
  2

• VCF annotator should have additional options/behavior in case where input already has annotations

  VCF annotator
  ga4gh/vrs-python#557 · Filter by author jsstevenson opened on Jun 25, 2025